Nature Genetics 33, 113 - 114 (2003)
Published online: 6 January 2003; | doi:10.1038/ng1078
Ciliary signaling goes down the tubesJames P. Calvet
Department of Biochemistry and Molecular Biology and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. jcalvet@kumc.edu
The focus of research on polycystic kidney disease (PKD) has recently shifted to the primary cilia of renal epithelial cells. A new study shows that the protein products of the genes mutated in PKD mediate mechanosensory calcium mobilization, suggesting that a disruption of fluid-flow sensing triggers abnormal cell proliferation and cyst growth.
|
