Institute of Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA.
Correspondence should be addressed to Kenneth R. Chien kchien@ucsd.edu
The spatially and temporally coordinated interaction between migratory cardiac precursors, endothelial cells and myogenic precursors leads to the formation of the highly differentiated cell lineages in the heart. In a new study, conditional mouse mutants are used to show that Nf1 signaling in cardiac endothelium is essential for proper heart formation.
