Nature Genetics
33, 8 - 9 (2003)
doi:10.1038/ng0103-8
Cre-constructing the heartPilar Ruiz-Lozano
& Kenneth R. Chien
Institute of Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA.
Correspondence should be addressed to Kenneth R. Chien kchien@ucsd.eduThe spatially and temporally coordinated interaction between migratory cardiac precursors, endothelial cells and myogenic precursors leads to the formation of the highly differentiated cell lineages in the heart. In a new study, conditional mouse mutants are used to show that Nf1 signaling in cardiac endothelium is essential for proper heart formation.
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