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Nature Genetics  33, 6 - 8 (2003)
doi:10.1038/ng0103-6

Quantitative epigenetics

Suzanne L. Rutherford & Steven Henikoff

Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. srutherf@fhcrc.org or steveh@fhcrc.org

Individuals display morphological variation when genetic buffering is reduced, allowing phenotypic differences to be selected for during successive generations. A new study shows that perturbations of chromatin-inheritance genes uncover morphological variation, and epigenetic variants can be rapidly selected. This finding extends our understanding of the means by which phenotypic variation is generated and brings chromatin inheritance into the realm of multigenic traits.

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RESEARCH
Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution
Nature Genetics Letters (01 Jan 2003)

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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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