1
Institute for Stem Cell Research, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JQ, UK. josh.brickman@ed.ac.uk
2
Department of Gene Expression and Development, Roslin Institute, Roslin, Midlothian EH25 9PS, UK. tom.burdon@bbsrc.ac.uk.
Pluripotent stem cells are essential for embryonic development and regeneration of adult tissues. But when the molecular pathways that control stem cells go awry, the result can often be the development of tumors. Wnt signaling mediated by the intracellular transducer -catenin and the tumor suppressor APC (adenomatosis polyposis coli) is pivotal in embryogenesis and frequently associated with cancer. The investigation of different mutations in Apc that lead to increased levels of -catenin in pluripotent cells supports the notion that many cancers may result from the dysregulation of stem-cell programs.
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