Abstract
We have recently shown that loss of heterozygosity of specific markers, including those at 10q23, 17p13–p15 and 16q24, can occur in the stromal and epithelial compartments of primary invasive breast carcinomas. Here, we demonstrate high frequencies of somatic mutations in TP53 (encoding tumor protein p53) and PTEN (encoding phosphate and tensin homolog) in breast neoplastic epithelium and stroma. Mutations in TP53 and PTEN are mutually exclusive in either compartment. In contrast, mutations in WFDC1 (16q24, encoding WAP four-disulfide core domain 1) occur with low frequency in the stroma.
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Acknowledgements
We are grateful to M. Ostrowski and G. Leone for helpful discussions and to C. Morrison, M. Prasad and A. Adewale for assistance. This work was supported in part by the Jimmy V Golf Classic Award for Translational Cancer Research from the V Foundation (to C.E.), the American Cancer Society (to C.E.), the Department of Defense US Army Breast Cancer Research Program (to P.H.W. and C.E.) and the National Cancer Institute (to The Ohio State University Comprehensive Cancer Center).
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Kurose, K., Gilley, K., Matsumoto, S. et al. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet 32, 355–357 (2002). https://doi.org/10.1038/ng1013
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DOI: https://doi.org/10.1038/ng1013
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