 | Figure 3
Nature Genetics
32, 438 - 442 (2002)
Published online: 30 September 2002; | doi:10.1038/ng1005
Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timingDirk Schübeler, David Scalzo, Charles Kooperberg, Bas van Steensel, Jeffrey Delrow
& Mark Groudine | | | | Figure 3. Replication profile for the sequenced D. melanogaster genome.
a, Profile of the processed data for the euchromatic arms of the D. melanogaster chromosomes. Bars above the x axis indicate distances greater than 100 kb between neighboring spots. b, Mitotic chromosomes of D. melanogaster. The sequenced euchromatin is shown in white and the heterochromatin in gray. c, Replication timing ratio for dispersed transposable elements, which showed significantly later replication timing (P < 10-6; 11 randomly chosen sequences of the unique 5,221 euchromatin spots had a higher average replication timing ratio than the 11 transposable elements shown here in all 1,000,000 samples). Of the transposable elements shown, Bari-1 and R1DM are localized exclusively to heterochromatin. They replicated later than 98% of the euchromatin sequences on the array, indicating late replication of heterochromatin. The other transposable elements listed are present in euchromatin and heterochromatin, and thus their replication timing represents the average of euchromatin and heterochromatin integration sites. Euchromatin, average of single-copy genes; dispersed, average of dispersed elements shown.
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