Department of Biochemistry and Molecular Biology, S.U.N.Y. Upstate Medical University, Syracuse, New York 13210, USA. gilbertd@upstate.edu
The long-presumed relationship between transcriptional activity of genes and their replication early in S-phase was challenged when a whole-genome analysis of replication timing in budding yeast found no such relationship. A new study reports the first genome-wide comparison of replication timing and gene expression in a multicellular organism, revealing a strong correlation between the two. This difference may reflect levels of nuclear organization that are important in the context of tissue-specific gene regulation.
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