Nature Genetics32, 340 - 341 (2002)
Published online: 7 October 2002; | doi:10.1038/ng1008
Uniting the paths to gene silencing
Craig S. Pikaard
& Richard J. Lawrence
Biology Department, Washington University, 1 Brookings Drive, St. Louis, Missouri 63122, USA. pikaard@biology.wustl.edu
A new study of ribosomal RNA gene silencing in the mouse provides clues as to how repressive chromatin states become established. At center stage is a chromatin remodeling complex that recruits DNA methyltransferase and histone deacetylase activities to the gene promoter, initiating a process that includes de novo DNA methylation, methylation of histone H3 on Lys9 and heterochromatin protein binding.
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