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Letter

Nature Genetics 32, 326–330 (1 October 2002) | doi:10.1038/ng957

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

Johane Robitaille , Marcia L.E. MacDonald , Ajamete Kaykas , Laird C. Sheldahl , Jutta Zeisler , Marie-Pierre Dub|[eacute]| , Lin-Hua Zhang , Roshni R. Singaraja , Duane L. Guernsey , Binyou Zheng , Lee F. Siebert , Ann Hoskin-Mott , Michael T. Trese , Simon N. Pimstone , Barkur S. Shastry , Randall T. Moon , Michael R. Hayden , Y. Paul Goldberg & Mark E. Samuels

Familial exudative vitreoretinopathy (FEVR) is a hereditary ocular disorder characterized by a failure of peripheral retinal vascularization. Loci associated with FEVR map to 11q13–q23 (EVR1; OMIM 133780, ref.