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Letter
Nature Genetics 32, 306–311 (1 October 2002) | doi:10.1038/ng997
Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis
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Abstract
The gene PTTG1 (encoding the pituitary tumor–transforming 1 protein) is overexpressed in several different tumor types, is tumorigenic in vivo and shows transcriptional activity. The PTTG1 protein is cell-cycle regulated and was identified as the human securin (a category of proteins involved in the regulation of sister-chromatid separation) on the basis of biochemical similarities with the Pds1p protein of budding yeast and the Cut2p protein of fission yeast.
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