1
Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
2
Programs in Development and Genetics, Research Institute, Hospital for Sick Children, Toronto, Canada, M5G 1X8. mcinnes@sickkids.ca
Excessive exposure to visible light damages the vertebrate retina. New work demonstrates that two different pathways, a bright-light pathway and a low-light dependent pathway, mediate light-induced retinal death. Although both pathways are initiated by excessive activation of the photopigment rhodopsin, they differ in that only the bright-light pathway is AP-1-dependent and only the low-light pathway is dependent on phototransduction.
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