Nature Genetics32, 221 - 222 (2002)
Published online: 16 September 2002; | doi:10.1038/ng1000
The tail does not always wag the dog
Karolin Luger
Department of Biochemistry & Molecular Biology, Colorado State University, Fort Collins, Colorado 80523, USA. kluger@lamar.colostate.edu
There is a growing awareness of the importance of chromatin modifications in regulating everything from gene expression to DNA replication. A new study extends our knowledge of how certain regions of the yeast genome are silenced into transcriptionally inactive domains, and offers strong evidence for new structural principles that may govern this process. These findings require us to revise our histone tail−centric view of chromatin silencing and other processes that affect chromatin structure.
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