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Letter

Nature Genetics 32, 153–159 (1 September 2002) | doi:10.1038/ng950

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer

Harald Mikkers , John Allen , Puck Knipscheer , Lieke Romeyn , Augustinus Hart , Edwin Vink & Anton Berns

Genetic screens carried out in lower organisms such as yeast, Drosophila melanogaster and Caenorhabditis elegans have revealed many signaling pathways. For example, components of the RAS signaling cascade were identified using a mutant eye phenotype in D.