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Letter

Nature Genetics 32, 201–205 (1 September 2002) | doi:10.1038/ng946

Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts

Patricia Hess , German Pihan , Charles L. Sawyers , Richard A. Flavell & Roger J. Davis

The c-Jun NH2-terminal kinase (JNK) is implicated in the apoptotic response of cells exposed to stress, but the JNK signal transduction pathway may not act exclusively in apoptosis. In some studies of tumor cells, JNK has been implicated in signaling cell survival.