Nature Genetics32, 83 - 84 (2002)
Published online: 12 August 2002; | doi:10.1038/ng960
A leukemogenic twist for GATA1
A. Thomas Look
Dana-Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA. thomas_look@dfci.harvard.edu
Mutations in the gene encoding the transcription factor GATA1 contribute to a specific type of leukemia in people with Down syndrome. This finding suggests a multistep pathway of leukemia development that involves GATA1 and one or more genes on chromosome 21.
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