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Journal home Advance online publication Current issue Archive Press releases Free Association (blog) Supplements Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Biotechnology Nature Cell Biology Nature Medicine Nature Methods Nature Reviews Cancer Nature Reviews Genetics Nature Reviews Molecular Cell Biology news@nature.com Nature Conferences Nature Reports Stem Cells RNAi Gateway NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications Brief Communication Nature Genetics  32, 107 - 108 (2002) Published online: 29 July 2002; | doi:10.1038/ng944 Efficient delivery of siRNA for inhibition of gene expression in postnatal mice David L. Lewis1, James E. Hagstrom1, Aaron G. Loomis1, Jon A. Wolff2 & Hans Herweijer1 1  Mirus Corporation, 505 South Rosa Road, Madison, Wisconsin 53719, USA. 2  Department of Pediatrics and Medical Genetics, Waisman Center, University of Wisconsin, Madison, Wisconsin, USA. Correspondence should be addressed to David L. Lewis davel@genetransfer.comIt has recently been shown that RNA interference can be induced in cultured mammalian cells by delivery of short interfering RNAs (siRNAs). Here we describe a method for efficient in vivo delivery of siRNAs to organs of postnatal mice and demonstrate effective and specific inhibition of transgene expression in a variety of organs. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated RESEARCH Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing Nature Biotechnology Research (01 Mar 2003) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature Letters to Editor (24 May 2001) Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate The EMBO Journal Article (03 Dec 2001)  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Save this link Open Innovation Challenges Efficient Chromosome Doubling: Plant Cell Division Deadline: Jul 15 2009 Reward: $20,000 USD The Seeker is looking for an efficient chromosome doubling method in plants and in particular, metho... Protect Enzyme from In Planta Degradation Deadline: Jul 15 2009 Reward: $20,000 USD A proposal for stable expression of an enzyme in corn seed is desired. More Challenges Powered by: nature jobs Canada Excellence Research Chair University of Waterloo Waterloo Candada Professorship in Biotechnology with a Special Focus on Biopharmaceutical Technology University of Natural Resources and Applied Life Sciences Vienna Vienna 1190 Austria More science jobs Post a job for free Competing financial interests Figures & Tables Supplementary info Export citation Search buyers guide:   ADVERTISEMENT

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