Molecular Genetics Program, Virginia Mason Research Center, Seattle, Washington 98101, USA. patcon@vmresearch.org
Biallelic mutations in ATM cause the recessive disorder ataxia-telangiectasia that is characterized by an increased susceptibility to cancer, but the link between single-copy ATM mutations and cancer has been more difficult to establish. New studies implicate missense mutations in ATM and suggest a model based on dominant interference in heterozygotes.
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