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Letter
Nature Genetics 31, 379–384 (1 August 2002) | doi:10.1038/ng926
Digenic inheritance of severe insulin resistance in a human pedigree
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Abstract
Impaired insulin action is a key feature of type 2 diabetes and is also found, to a more extreme degree, in familial syndromes of insulin resistance. Although inherited susceptibility to insulin resistance may involve the interplay of several genetic loci, no clear examples of interactions among genes have yet been reported.
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