Nature Genetics31, 333 - 334 (2002)
Published online: 1 July 2002; | doi:10.1038/ng933
Complement in glomerulonephritis
Thomas R. Welch
Department of Pediatrics, Upstate Medical University, Syracuse, New York 13210, USA. welcht@upstate.edu
Decades after the first report of a complement-activating factor in the serum of some people with chronic glomerulonephritis, its causal role in the disease is still debated. In a new study, mice engineered to lack a regulatory protein, factor H, uniformly develop glomerulonephritis, and have ongoing consumption of serum complement similar to that seen in humans.
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