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Letter

Nature Genetics 31, 276–278 (1 July 2002) | doi:10.1038/ng921

Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract

Lei Bu , Yiping Jin , Yuefeng Shi , Renyuan Chu , Airong Ban , Hans Eiberg , Lisa Andres , Haisong Jiang , Guangyong Zheng , Meiqian Qian , Bin Cui , Yu Xia , Jing Liu , Landian Hu , Guoping Zhao , Michael R. Hayden & Xiangyin Kong

Congenital cataracts cause 10–30% of all blindness in children, with one-third of cases estimated to have a genetic cause. Lamellar cataract is the most common type of infantile cataract.