Nature Genetics
31, 239 - 240 (2002)
Published online: 17 June 2002; | doi:10.1038/ng913
Identification of SLC39A4, a gene involved in acrodermatitis enteropathicaSébastien Küry1, Brigitte Dréno2, Stéphane Bézieau1, Stéphanie Giraudet1, Monia Kharfi3, Ridha Kamoun3
& Jean-Paul Moisan11
Laboratoire d'Etude du Polymorphisme de l'ADN, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex, France. 2
Service de Dermatologie, Hôtel-Dieu, Centre Hospitalier Universitaire, 44093 Nantes Cedex, France. 3
Service de Dermatologie, Hôpital Charles Nicolle, Tunis, Tunisia.
Correspondence should be addressed to Sébastien Küry skury@sante.univ-nantes.frWe have characterized the human gene SLC39A4, which encodes a protein with features characteristic of a ZIP zinc transporter. The chromosomal location and expression of SLC39A4, together with mutational analysis of eight families affected with acrodermatitis enteropathica, suggest that SLC39A4 is centrally involved in the pathogenesis of this condition.
|
