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Letter

Nature Genetics 31, 180–183 (1 June 2002) | doi:10.1038/ng887

Clustering of housekeeping genes provides a unified model of gene order in the human genome

Martin J. Lercher , Araxi O. Urrutia & Laurence D. Hurst

It is often supposed that, except for tandem duplicates, genes are randomly distributed throughout the human genome. However, recent analyses suggest that when all the genes expressed in a given tissue (notably placenta and skeletal muscle) are examined, these genes do not map to random locations but instead resolve to clusters.