Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA.lbrody@helix.nih.gov
Two highly penetrant loci have been linked to familial breast cancer (BRCA1 and BRCA2), but do not explain most breast cancer familial aggregation. A new study suggests that a variant in a gene involved in DNA repair may account for some of this unexplained risk.
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