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Letter

Nature Genetics 30, 416–420 (1 April 2002) | doi:10.1038/ng859

c-fos regulates neuronal excitability and survival

Jianhua Zhang , Dongsheng Zhang , Jill Slane McQuade , Michael Behbehani , Joe Z. Tsien & Ming Xu

Excitotoxicity is a process in which glutamate or other excitatory amino acids induce neuronal cell death. Accumulating evidence suggests that excitotoxicity may contribute to human neuronal cell loss caused by acute insults and chronic degeneration in the central nervous system.