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Letter

Nature Genetics 30, 406–410 (1 April 2002) | doi:10.1038/ng849

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

Ian P.M. Tomlinson , N. Afrina Alam , Andrew J. Rowan , Ella Barclay , Emma E. M. Jaeger , David Kelsell , Irene Leigh , Patricia Gorman , Hanan Lamlum , Shamima Rahman , Rebecca R. Roylance , Simon Olpin , Stephen Bevan , Karen Barker , Nicholas Hearle , Richard S. Houlston , Maija Kiuru , Rainer Lehtonen , Auli Karhu , Susa Vilkki , P|[auml]|ivi Laiho , Carita Eklund , Outi Vierimaa , Kristiina Aittom|[auml]|ki , Marja Hietala , Pertti Sistonen , Anders Paetau , Reijo Salovaara , Riitta Herva , Virpi Launonen & Lauri A. Aaltonen

Uterine leiomyomata (fibroids) are common and clinically important tumors, but little is known about their etiology and pathogenesis. We previously mapped a gene that predisposes to multiple fibroids, cutaneous leiomyomata and renal cell carcinoma to chromosome 1q42.3–q43 (refs 4–6).