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Small changes in expression affect predisposition to tumorigenesis

Abstract

We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.

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Figure 1: Reduced expression of one allele in affected individuals with FAP.
Figure 2: Loss-of-heterozygosity analysis.

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References

  1. Johnson, N.A. & Porter, A.H. J. Theor. Biol. 205, 527–542 (2000).

    Article  CAS  Google Scholar 

  2. Antonarakis, S.E., Krawczak, M. & Cooper, D.N. The Metabolic and Molecular Bases of Inherited Disease . (eds Scriver, C.R. et al.) 356–358 (McGraw-Hill, Toronto, 2001).

    Google Scholar 

  3. Kinzler, K.W. & Vogelstein, B. Cell 87, 159–170 (1996).

    Article  CAS  Google Scholar 

  4. Laken, S.J. et al. Proc. Natl Acad. Sci. USA 96, 2322–2326 (1999).

    Article  CAS  Google Scholar 

  5. Yan, H. et al. Nature 403, 723–724 (2000).

    Article  CAS  Google Scholar 

  6. Zhou, W. et al. Nature Biotechnol. 19, 78–81 (2001).

    Article  CAS  Google Scholar 

  7. Jaiswal, A.S. & Narayan, S. J. Cell Biochem. 81, 262–277 (2001).

    Article  CAS  Google Scholar 

  8. Solomon, E. et al. Nature 328, 616–619 (1987).

    Article  CAS  Google Scholar 

  9. Shih, I.M. et al. Cancer Res. 61, 818–822 (2001).

    CAS  Google Scholar 

  10. Royall, R. Statistical Evidence: A Likelihood Paradigm (Chapman and Hall, London, 1997).

    Google Scholar 

Download references

Acknowledgements

This work was supported by grants from the National Institutes of Health.

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Correspondence to Bert Vogelstein.

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Yan, H., Dobbie, Z., Gruber, S. et al. Small changes in expression affect predisposition to tumorigenesis. Nat Genet 30, 25–26 (2002). https://doi.org/10.1038/ng799

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