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Nature Genetics  29, 365 - 371 (2001)

Minimum information about a microarray experiment (MIAME)—toward standards for microarray data

Alvis Brazma1, Pascal Hingamp2, John Quackenbush3, Gavin Sherlock4, Paul Spellman5, Chris Stoeckert6, John Aach7, Wilhelm Ansorge8, Catherine A. Ball4, Helen C. Causton9, Terry Gaasterland10, Patrick Glenisson11, Frank C.P. Holstege12, Irene F. Kim4, Victor Markowitz13, John C. Matese4, Helen Parkinson1, Alan Robinson1, Ugis Sarkans1, Steffen Schulze-Kremer14, Jason Stewart15, Ronald Taylor16, Jaak Vilo1 & Martin Vingron17

1  European Bioinformatics Institute, EMBL outstation, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

2  Centre d'Immunologie de Marseille Luminy (CIML TAGC) & Université de la Méditerranée, Marseille, France.

3  The Institute for Genomic Research (TIGR), Rockville, Maryland, USA.

4  Stanford University, Palo Alto, California, USA.

5  University of California Berkeley, Berkeley, California, USA.

6  University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7  Department of Genetics, Harvard Medical School, Cambridge, Massachusetts, USA.

8  European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

9  CSC/Imperial College School of Medicine Microarray Centre, London, UK.

10  Rockefeller University, New York, New York, USA.

11  Katholieke Universiteit Leuven, Leuven, Belgium.

12  University Medical Center, Utrecht, Netherlands.

13  GeneLogic Inc, Gaithersburg, Maryland, USA.

14  RZDP German Genome Resource Center, Berlin, Germany.

15  Open Informatics, Albuquerque, New Mexico, USA.

16  Center for Computational Pharmacology, University of Colorado School of Medicine, Denver, Colorado, USA.

17  Max Plank Institute for Molecular Genetics, Berlin, Germany.

Correspondence should be addressed to Alvis Brazma or John Quackenbush
Microarray analysis has become a widely used tool for the generation of gene expression data on a genomic scale. Although many significant results have been derived from microarray studies, one limitation has been the lack of standards for presenting and exchanging such data. Here we present a proposal, the Minimum Information About a Microarray Experiment (MIAME), that describes the minimum information required to ensure that microarray data can be easily interpreted and that results derived from its analysis can be independently verified. The ultimate goal of this work is to establish a standard for recording and reporting microarray-based gene expression data, which will in turn facilitate the establishment of databases and public repositories and enable the development of data analysis tools. With respect to MIAME, we concentrate on defining the content and structure of the necessary information rather than the technical format for capturing it.

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Human Genetics: Online Resources
Nature Encyclopaedia of Life Sciences

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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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