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Letter

Nature Genetics 29, 306–309 (1 November 2001) | doi:10.1038/ng749

Replication validity of genetic association studies

John P.A. Ioannidis , Evangelia E. Ntzani , Thomas A. Trikalinos & Despina G. Contopoulos-Ioannidis

The rapid growth of human genetics creates countless opportunities for studies of disease association. Given the number of potentially identifiable genetic markers and the multitude of clinical outcomes to which these may be linked, the testing and validation of statistical hypotheses in genetic epidemiology is a task of unprecedented scale.