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Letter

Nature Genetics 29, 233–237 (1 October 2001) | doi:10.1038/ng1001-233

Haplotype tagging for the identification of common disease genes

Gillian C.L. Johnson , Laura Esposito , Bryan J. Barratt , Annabel N. Smith , Joanne Heward , Gianfranco Di Genova , Hironori Ueda , Heather J. Cordell , Iain A. Eaves , Frank Dudbridge , Rebecca C.J. Twells , Felicity Payne , Wil Hughes , Sarah Nutland , Helen Stevens , Phillipa Carr , Eva Tuomilehto-Wolf , Jaakko Tuomilehto , Stephen C.L. Gough , David G. Clayton & John A. Todd

Genome-wide linkage disequilibrium (LD) mapping of common disease genes could be more powerful than linkage analysis if the appropriate density of polymorphic markers were known and if the genotyping effort and cost of producing such an LD map could be reduced. Although different metrics that measure the extent of LD have been evaluated, even the most recent studies have not placed significant emphasis on the most informative and cost-effective method of LD mapping—that based on haplotypes.