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Letter

Nature Genetics 28, 350–354 (1 August 2001) | doi:10.1038/ng571

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease

Andrew R.J. Curtis , Constanze Fey , Christopher M Morris , Laurence A. Bindoff , Paul G. Ince , Patrick F. Chinnery , Alan Coulthard , Margaret J. Jackson , Andrew P. Jackson , Duncan P. McHale , David Hay , William A. Barker , Alex F. Markham , David Bates , Ann Curtis & John Burn

We describe here a previously unknown, dominantly inherited, late-onset basal ganglia disease, variably presenting with extrapyramidal features similar to those of Huntington's disease (HD) or parkinsonism. We mapped the disorder, by linkage analysis, to 19q13.3, which contains the gene for ferritin light polypeptide (FTL).