Genome Sciences Department, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. mdbiggin@lbl.gov
Gene expression is regulated by transcription factors binding selectively to particular portions of the genome. To what extent are these protein−DNA interactions influenced by the intrinsic sequence-specific recognition properties at each protein, and to what extent are they affected by other factors, such as chromatin structure or cooperative interactions with other proteins. Genome-wide surveys of DNA binding by transcription factors in vivo are beginning to provide some answers.
