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Brief Communication

Nature Genetics 28, 216–217 (1 July 2001) | doi:10.1038/90046

Sox9 induces testis development in XX transgenic mice

Valerie P.I. Vidal , Marie-Christine Chaboissier , Dirk G. de Rooij & Andreas Schedl

Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads.