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Brief Communication

Nature Genetics 28, 220–221 (1 July 2001) | doi:10.1038/90054

Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia

Zhigui Ma , Stephan W. Morris , Virginia Valentine , Martin L , Jo-Anne Herbrick , Xiaoli Cui , Derek Bouman , Yue Li , Perdeep K. Mehta , Dean Nizetic , Yasuhiko Kaneko , Godfrey C.F. Chan , Li C. Chan , Jeremy Squire , Stephen W. Scherer & Johann K. Hitzler

t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.