 | Figure 4
Nature Genetics
28, 276 - 280 (2001)
doi:10.1038/90123
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiationYukio Hiroi, Sumiyo Kudoh, Koshiro Monzen, Yuichi Ikeda, Yoshio Yazaki, Ryozo Nagai
& Issei Komuro | | | | Figure 4. Expression of cardiac genes in P19CL6 cell lines.
Data represent expression of Nkx2-5, Gata4, Mef2c, Myl2, Atp2a2 and Nppa on day 8 and Crap expression on day 10. The cell line expressing wildtype Tbx5 (WT) expresses all these cardiac genes more abundantly than parental P19CL6 cells but expression of all the cardiac genes is markedly suppressed in the cell line expressing the G80R mutant. These three cell lines expressed similar amounts of exogenous Tbx5 and its mutants (exogenous Tbx5). 28S RNA demonstrates equal loading of samples.
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