Abstract
t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Carroll, A. et al. Blood 78, 748–752 (1991).
Lion, T. et al. Blood 79, 3325–3330 (1992).
Bernstein, J. et al. Leukemia 14, 216–217 (2000).
Kozak, M. Mamm. Genome 7, 563–574 (1996).
Aravind, L. & Koonin, E. Trends Biochem. Sci. 25, 112–114 (2000).
Nayler, O. et al. Nucleic Acids Res. 26, 3542–3549 (1998).
Lupas, A. Trends Biochem. Sci. 21, 375–382 (1996).
Mitchell, P. & Tjian, R. Science 245, 372–378 (1989).
Prasad, R. et al. Oncogene 15, 549–560 (1997).
Burd, C. & Dreyfuss, G. Science 265, 615–620 (1994).
Wiellette, E. et al. Development 126, 5373–7385 (1999).
Newberry, E., Latifi, T. & Towler, D. Biochemistry 38, 10678–10690 (1999).
Rebay, I. et al. Genetics 154, 695–712 (2000).
Chen, F. & Rebay, I. Curr. Biol. 10, 943–946 (2000).
Kuang, B. et al. Development 127, 1517–1529 (2000).
Acknowledgements
We thank C. Lee, IWK Grace Health Centre, Halifax, NS, and E. Separovic, British Columbia Children's Hospital, Vancouver, BC, Canada, for help in identifying leukemia cell samples; J. Skaug and The Centre for Applied Genomics at The Hospital for Sick Children for excellent technical assistance; I. Herrington and V. Audino for manuscript preparation; and J. Downing and J. Dick for comments regarding the manuscript. This research was supported in part by grant CA-87064 (to S.W.M.) and Cancer Center Support (CORE) grant CA-27165, both from the National Cancer Institute, by the American Lebanese Syrian Associated Charities (ALSAC), St Jude Children's Research Hospital, and by The Hospital for Sick Children Foundation. S.W.S. is the recipient of a CIHR Scholar Award.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Ma, Z., Morris, S., Valentine, V. et al. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28, 220–221 (2001). https://doi.org/10.1038/90054
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/90054
This article is cited by
-
c-Mpl-del, a c-Mpl alternative splicing isoform, promotes AMKL progression and chemoresistance
Cell Death & Disease (2022)
-
MKL-1 is a coactivator for STAT5b, the regulator of Treg cell development and function
Cell Communication and Signaling (2020)
-
The pan-cancer landscape of netrin family reveals potential oncogenic biomarkers
Scientific Reports (2020)
-
RNA-modifying proteins as anticancer drug targets
Nature Reviews Drug Discovery (2018)
-
Molecular analysis of an asbestos-exposed Belgian family with a high prevalence of mesothelioma
Familial Cancer (2018)