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Brief Communication
Nature Genetics  28, 220 - 221 (2001)
doi:10.1038/90054

Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia

Zhigui Ma1, Stephan W. Morris1, 3, 5, Virginia Valentine2, Martin L12, Jo-Anne Herbrick12, Xiaoli Cui1, Derek Bouman14, Yue Li11, Perdeep K. Mehta4, Dean Nizetic6, Yasuhiko Kaneko7, Godfrey C.F. Chan8, Li C. Chan9, Jeremy Squire13, 14, Stephen W. Scherer12, 15 & Johann K. Hitzler10, 11

1  Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

2  Department of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

3  Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

4  Hartwell Center for Bioinformatics and Biotechnology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

5  Department of Pediatrics, University of Tennessee, College of Medicine, Memphis, Tennessee 38163, USA.

6  Centre for Applied Molecular Biology, School of Pharmacy, University of London, WC1N 1AX, UK.

7  Department of Cancer Chemotherapy, Saitama Cancer Center Hospital, Ina, Saitama, 363-0806, Japan.

8  Department of Paediatrics, Division of Haematology, Queen Mary Hospital, University of Hong Kong, PRC.

9  Department of Pathology, Division of Haematology, Queen Mary Hospital, University of Hong Kong, PRC.

10  Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada.

11  Department of Cancer and Blood, The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada.

12  Department of Genetics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada.

13  Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

14  Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

15  Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

Correspondence should be addressed to Johann K. Hitzler johann.hitzler@sickkids.on.ca or Stephan W. Morris steve.morris@stjude.org
t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.


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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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