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Sox9 induces testis development in XX transgenic mice

Abstract

Mutations in SOX9 are associated with male-to-female sex reversal in humans1,2. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.

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Figure 1: Construct design and analysis of transgenic animals.
Figure 2: Analysis of gonads in wildtype and transgenic animals.

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Acknowledgements

We thank U. Ziegler, S. Schmidt, S. Lützkendorf and D. Landrock for excellent technical assistance. This work was supported by the Volkswagen Stiftung and EC-grant QLRT00741.

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Correspondence to Andreas Schedl.

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Vidal, V., Chaboissier, MC., de Rooij, D. et al. Sox9 induces testis development in XX transgenic mice. Nat Genet 28, 216–217 (2001). https://doi.org/10.1038/90046

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