Nature Genetics
28, 216 - 217 (2001)
doi:10.1038/90046
Sox9 induces testis development in XX transgenic miceValerie P.I. Vidal1, 4, Marie-Christine Chaboissier1, 4, Dirk G. de Rooij2
& Andreas Schedl1, 31
MDC for Molecular Medicine, Robert-Rössle-Strasse 10, 13092 Berlin, Germany. 2
Department of Cell Biology, University Medical Center Utrecht, Utrecht, Netherlands. 3
Present address: Institute of Human Genetics, University of Newcastle upon Tyne, UK. 4
These authors contributed equally to this work.
Correspondence should be addressed to Andreas Schedl andreas.schedl@ncl.ac.ukMutations in SOX9 are associated with male-to-female sex reversal in humans1,
2. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.
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