Nature Genetics
28, 105 - 107 (2001)
doi:10.1038/88802
To be or not to BMPCharis Eng
Clinical Cancer Genetics and Human Cancer Genetics Programs, Comprehensive Cancer Center, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA; CRC Human Cancer Genetics Research Group, University of Cambridge, Cambridge CB2 2QQ, United Kingdom. eng-1@medctr.osu.edu
Three years after MADH4 (also known as SMAD4) was identified as a gene critical to juvenile polyposis, BMPR1A, encoding a receptor in the same pathway, has been identified as another susceptibility gene. The TGF /BMP superfamily of molecules has not only been shown to be defective in neoplasia but also in the non-cancer developmental syndromes primary pulmonary hypertension and hereditary hemorrhagic telangiectasia.
|
