Center for Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390, USA. parada@utsw.swmed.edu
Type 1 neurofibromatosis is a syndrome caused by mutation of the gene NF1, which encodes neurofibromin—a tumor suppressor related to the Ras GAP signaling proteins. A new study of mice that lack a splice variant of neurofibromin discloses learning impairments similar to those of people with neurofibromatosis, and raises questions about the signaling pathways implicating neurofibromin isoforms during synaptic plasticity.
