Nature Genetics
27, 10 - 11 (2001)
doi:10.1038/83657
Cytoskeletal catastrophe causes brain degenerationRoy Quinlan
Department of Biological Sciences, South
Road, Durham DH1 3LE, UK.
r.a.quinlan@durham.ac.uk
A number of spontaneous mutations in GFAP, encoding an astrocyte-specific
intermediate filament protein, causes a neurodegenerative disease. It seems
probable that these mutations effect gain of function of the GFAP filament
and thereby have an impact on the cytoskeletal architecture and interactions.
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