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Letter

Nature Genetics 26, 490–494 (1 December 2000) | doi:10.1038/82652

A transgenic insertion upstream of Sox9 is associated with dominant XX sex reversal in the mouse

Colin E. Bishop , Deanne J. Whitworth , Yanjun Qin , Alexander I. Agoulnik , Irina U. Agoulnik , Wilbur R. Harrison , Richard R. Behringer & Paul A. Overbeek

In most mammals, male development is triggered by the transient expression of the Y-chromosome gene, Sry, which initiates a cascade of gene interactions ultimately leading to the formation of a testis from the indifferent fetal gonad. Several genes, in particular Sox9, have a crucial role in this pathway.