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Letter
Nature Genetics 26, 490–494 (1 December 2000) | doi:10.1038/82652
A transgenic insertion upstream of Sox9 is associated with dominant XX sex reversal in the mouse
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Abstract
In most mammals, male development is triggered by the transient expression of the Y-chromosome gene, Sry, which initiates a cascade of gene interactions ultimately leading to the formation of a testis from the indifferent fetal gonad. Several genes, in particular Sox9, have a crucial role in this pathway.
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