Nature Genetics
26, 257 - 258 (2000)
doi:10.1038/81529
When more is betterJohn H J Petrini
Laboratory of Genetics, University of Wisconsin Medical School, Madison, Wisconsin, USA.
jpetrini@facstaff.wisc.edu
Nucleotide excision repair (NER) is a highly conserved multi-step
process. Congenital NER defects are clinically complex, at least in part because
components of the NER machinery also function in the basal transcription factor,
TFIIH. A new study demonstrates that reduction in the amount, rather than
the inherent activity, of TFIIH is the underlying cause of one such congenital
NER defect, underscoring the link between transcription and NER-associated
disease.
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