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Volume 26 Issue 2, October 2000

Editorial

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News & Views

  • Apart from resistance to infectious disease, there are few examples of adaptive molecular evolution in humans. A new study indicates that olfactory receptors are exceptions, with natural selection maintaining considerable allelic diversity in this multigene family.

    • Mark Seielstad
    News & Views
  • The inability to construct animal models of human diseases caused by mutated mitochondrial DNA (mtDNA) has been a major obstacle to investigating pathogenetic mechanisms associated with specific mtDNA mutations. Mice carrying a large-scale deletion in mtDNA have now been produced. They display some of the key features of the human disorder, but there are surprising differences.

    • Eric A Shoubridge
    News & Views
  • Pair-wise genome comparisons offer new sources of information about the patterns and processes that influence genomic designs. Replication-dependent rearrangements, as indicated by the symmetric gene organization pattern in the genomes of Chlamydia pneumoniae and Chlamydia trachomatis, may provide a missing link in the reconstruction of historical events from modern genomes.

    • Siv GE Andersson
    News & Views
  • Positional cloning of common disease genes is a central but elusive goal of human geneticists. Progress is now reported by Bell and colleagues in their study of NIDDM1, a locus implicated in type 2 diabetes. The complex nature of the reported association illustrates the challenge of implicating a specific gene and mutation in the causation of polygenic disease.

    • David Altshuler
    • Mark Daly
    • Leonid Kruglyak
    News & Views
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Brief Communication

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Book Review

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Commentary

  • “They all talked at once, their voices insistent and contradictory and impatient, making of unreality a possibility, then a probability, then an incontrovertible fact, as people will when their desires become words.” —W. Faulkner, The Sound and the Fury, 1929

    • Kenneth M. Weiss
    • Joseph D. Terwilliger
    Commentary
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Progress

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Letter

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