Nature Genetics
26, 159 - 161 (2000)
doi:10.1038/82825
Choose your targetMario R Capecchi
Howard Hughes Medical Institute, Department of Human
Genetics, University of Utah School of Medicine, Salt Lake City
, Utah, USA
mario.capecchi@genetics.utah.edu
The technology of modifying endogenous genes has recently been extended
from mice to Drosophila and sheep. Concurrently, genomic sequencing
is uncovering thousands of previously uncharacterized genes. Armed with today's
technologies, what are our best options for delineating the functions of these
new genes?
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