Nature Genetics
25, 255 - 257 (2000)
doi:10.1038/77000
Mitochondrial DNA heteroplasmy in cloned cattle produced by fetal and
adult cell cloningRalf Steinborn1, 2, Pamela Schinogl1, Valeri Zakhartchenko4, Roland Achmann2, Wolfgang Schernthaner4, Miodrag Stojkovic4, Eckhard Wolf4, Mathias Müller1
& Gottfried Brem1, 2, 31
Institute of Animal Breeding Genetics, University of
Veterinary Medicine, Vienna, Austria
2
Ludwig-Boltzmann Institute for Immuno- Cyto- and Molecular
Genetic Research, Vienna, Austria
3
Department of Biotechnology in Animal Production, Institute
for Agrobiotechnology, Tulln, Austria
4
Department of Molecular Animal Breeding and Genetics,
Gene Center, Ludwig-Maximilian University, Munich,
Germany
Correspondence should be addressed to Ralf Steinborn Ralf.Steinborn@vu-wien.ac.atMammals have been cloned from adult donor cells1,
2,
3. Here
we report the first cases of mitochondrial DNA (mtDNA) heteroplasmy in adult
mammalian clones generated from fetal and adult donor cells. The heteroplasmic
clones included a healthy cattle equivalent of the sheep Dolly, for which
a lack of heteroplasmy was reported4.
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