Department of Immunology, University Hospital and Centre
for Biomedical Genetics, Utrecht, Netherlands.
h.clevers@lab.azu.nl
A gene (AXIN1) encoding another component of the Wnt-signalling
pathway is reported to be mutated in human tumours, underscoring the oncogenic
consequences of inappropriate activation of developmental signalling pathways
later in life. Inhibitors of these signals therefore represent potential agents
with which to treat cancer.
