Division of Endocrinology, Beth Israel Deaconess Medical
Center, 330 Brookline Avenue, Brookline,
Massachusetts 02215, USA. jflier@bidmc.harvard.edu
.
Autosomal dominant partial lipdystrophy (PLD), in which regional adipose
loss is coupled with insulin resistance, is strongly associated with missense
mutations in LMNA, encoding lamin A/C—a component of the nuclear
envelope. This finding indicates that other proteins and functions of the
nuclear envelope may have bearing on disorders of adipose tissue and insulin
action.
