Division of Human Biology, Fred Hutchinson Cancer Research
Center, 1100 Fairview Avenue North, Seattle,
Washington 98109-1024, USA. memerman@fhcrc.org
The advantage that vectors derived from the human immunodeficiency virus
offer over other gene-delivery vehicles is their ability to transduce non-proliferative
tissues. But a report by Park et al. suggests that HIV-based vectors
are not able to infect all non-dividing cells and that host cell activation
may influence efficiency of gene delivery.
