Nature Genetics
24, 15 - 16 (2000)
doi:10.1038/71626
The Fanconi anaemia gene FANCF encodes a novel protein with homology
to ROMJohan P. de Winter1, Martin A. Rooimans1, Laura van der Weel1, Carola G.M. van Berkel1, Noa Alon2, Lucine Bosnoyan-Collins2, Jan de Groot3, Yu Zhi4, Quinten Waisfisz1, Jan C. Pronk1, Fré Arwert1, Christopher G. Mathew5, Rik J. Scheper3, Maureen E. Hoatlin4, Manuel Buchwald2
& Hans Joenje11
Department of Clinical Genetics and Human Genetics,
Free University, Amsterdam, The Netherlands. 2
Program in Genetics and Genomic Biology, The Hospital
for Sick Children, and Department of Molecular and Medical Genetics, The University
of Toronto, Toronto, Ontario, Canada.
3
Department of Pathology, Free University Hospital,
Amsterdam, The Netherlands. 4
Division of Hematology and Medical Oncology, Oregon
Health Sciences University, Portland, Oregon,
USA. 5
Division of Medical and Molecular Genetics, GKT School
of Medicine, Guy's Hospital, London, UK.
Correspondence should be addressed to Hans Joenje H.Joenje.HumGen@med.vu.nl.Fanconi anaemia (FA) is a chromosomal instability syndrome with autosomal
recessive inheritance. We have identified the gene mutated in Fanconi anaemia
group F patients by complementation cloning. FANCF has no introns and
encodes a polypeptide with homology to the prokaryotic RNA binding protein
ROM.
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