Quangeng Zhang1, 15, Reiner Siebert14, 15, Minhong Yan5, 15, Bernd Hinzmann6, 15, Xiaoli Cui1, 15, Liquan Xue1, Karen M. Rakestraw3, Clayton W. Naeve3, Georg Beckmann6, Dennis D. Weisenburger7, Warren G. Sanger8, 9, Hadwiga Nowotny10, Michael Vesely11, Evelyne Callet-Bauchu12, Gilles Salles13, Vishva M. Dixit5, André Rosenthal6, Brigitte Schlegelberger14
& Stephan W. Morris1, 2, 41
Department of Pathology and Laboratory Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
2
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
3
Center for Biotechnology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
4
Department of Pediatrics, University of Tennessee, College of Medicine, Memphis, Tennessee 38163, USA.
5
Department of Molecular Oncology, Genentech, Inc., South San Francisco, California 94080, USA.
6
metaGen Gesellschaft für Genomforschung mbH, Ihnestrasse 63, D-14195, Berlin, Germany.
7
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5440, USA.
8
Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska 68198-5440, USA.
9
Center for Human Genetics, University of Nebraska Medical Center, Omaha, Nebraska 68198-5440, USA.
10
Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, A-1140 Vienna, Austria.
11
Jakob Erdheim Institute of Pathology, Hospital Lainz, A-1130 Vienna, Austria.
12
Laboratoire d' Hématologie, Centre Hospitalier Lyon-Sud-Université Claude Bernard, 69495 ierre-Bénite, France
13
Service d' Hématologie, Centre Hospitalier Lyon-Sud-Université Claude Bernard, 69495 ierre-Bénite, France.
14
Department of Human Genetics, University of Kiel, D-24105 Kiel, Germany.
15
These authors contributed equally to this work.
Correspondence should be addressed to Stephan W. Morris steve.morris@stjude.org or Brigitte Schlegelberger brigitte@medger.uni-kiel.de
B but induced apoptosis of MCF7
and 293 cells. CARD-truncation mutants were unable to induce cell death or
activate NF-
